Buffer overflow vulnerabilities in CUDA: a preliminary analysis

We present a preliminary study of buffer overflow vulnerabilities in CUDA software running on GPUs. We show how an attacker can overrun a buffer to corrupt sensitive data or steer the execution flow by overwriting function pointers, e.g., manipulating the virtual table of a C++ object. In view of a potential mass market diffusion of GPU accelerated software this may be a major concern.Comment: 12 pages, 2 figure

Microprocessor fault-tolerance via on-the-fly partial reconfiguration

This paper presents a novel approach to exploit FPGA dynamic partial reconfiguration to improve the fault tolerance of complex microprocessor-based systems, with no need to statically reserve area to host redundant components. The proposed method not only improves the survivability of the system by allowing the online replacement of defective key parts of the processor, but also provides performance graceful degradation by executing in software the tasks that were executed in hardware before a fault and the subsequent reconfiguration happened. The advantage of the proposed approach is that thanks to a hardware hypervisor, the CPU is totally unaware of the reconfiguration happening in real-time, and there's no dependency on the CPU to perform it. As proof of concept a design using this idea has been developed, using the LEON3 open-source processor, synthesized on a Virtex 4 FPG

Pichia pastoris Fep1 is a [2Fe-2S] protein with a Zn finger that displays an unusual oxygen-dependent role in cluster binding

Fep1, the iron-responsive GATA factor from the methylotrophic yeast Pichia pastoris, has been characterised both in vivo and in vitro. This protein has two Cys(2)-Cys(2) type zinc fingers and a set of four conserved cysteines arranged in a Cys-X-5-Cys-X-8-Cys-X-2-Cys motif located between the two zinc fingers. Electronic absorption and resonance Raman spectroscopic analyses in anaerobic and aerobic conditions indicate that Fep1 binds iron in the form of a [2Fe-2S] cluster. Site-directed mutagenesis shows that replacement of the four cysteines with serine inactivates this transcriptional repressor. Unexpectedly, the inactive mutant is still able to bind a [2Fe-2S] cluster, employing two cysteine residues belonging to the first zinc finger. These two cysteine residues can act as alternative cluster ligands selectively in aerobically purified Fep1 wild type, suggesting that oxygen could play a role in Fep1 function by causing differential localization of the [Fe-S] cluster

On the Analysis of Public-Key Cryptologic Algorithms

The RSA cryptosystem introduced in 1977 by Ron Rivest, Adi Shamir and Len Adleman is the most commonly deployed public-key cryptosystem. Elliptic curve cryptography (ECC) introduced in the mid 80's by Neal Koblitz and Victor Miller is becoming an increasingly popular alternative to RSA offering competitive performance due the use of smaller key sizes. Most recently hyperelliptic curve cryptography (HECC) has been demonstrated to have comparable and in some cases better performance than ECC. The security of RSA relies on the integer factorization problem whereas the security of (H)ECC is based on the (hyper)elliptic curve discrete logarithm problem ((H)ECDLP). In this thesis the practical performance of the best methods to solve these problems is analyzed and a method to generate secure ephemeral ECC parameters is presented. The best publicly known algorithm to solve the integer factorization problem is the number field sieve (NFS). Its most time consuming step is the relation collection step. We investigate the use of graphics processing units (GPUs) as accelerators for this step. In this context, methods to efficiently implement modular arithmetic and several factoring algorithms on GPUs are presented and their performance is analyzed in practice. In conclusion, it is shown that integrating state-of-the-art NFS software packages with our GPU software can lead to a speed-up of 50%. In the case of elliptic and hyperelliptic curves for cryptographic use, the best published method to solve the (H)ECDLP is the Pollard rho algorithm. This method can be made faster using classes of equivalence induced by curve automorphisms like the negation map. We present a practical analysis of their use to speed up Pollard rho for elliptic curves and genus 2 hyperelliptic curves defined over prime fields. As a case study, 4 curves at the 128-bit theoretical security level are analyzed in our software framework for Pollard rho to estimate their practical security level. In addition, we present a novel many-core architecture to solve the ECDLP using the Pollard rho algorithm with the negation map on FPGAs. This architecture is used to estimate the cost of solving the Certicom ECCp-131 challenge with a cluster of FPGAs. Our design achieves a speed-up factor of about 4 compared to the state-of-the-art. Finally, we present an efficient method to generate unique, secure and unpredictable ephemeral ECC parameters to be shared by a pair of authenticated users for a single communication. It provides an alternative to the customary use of fixed ECC parameters obtained from publicly available standards designed by untrusted third parties. The effectiveness of our method is demonstrated with a portable implementation for regular PCs and Android smartphones. On a Samsung Galaxy S4 smartphone our implementation generates unique 128-bit secure ECC parameters in 50 milliseconds on average

Fantozzi. L'eterno ritorno

The idea behind this videoessay is that actor Paolo Villaggio has been gradually "swallowed" by his most famous character, the humble accountant Ugo Fantozzi, of which Villaggio, in his television debut, told the misadventures using third person narration.In 1975, when Fantozzi became a movie character, Villaggio decided to assume in first person the main role. But the intensive exploitation of the character, coupled with the rapid exhaustion of his creative vein, have forced the author-actor to a draining repetition of the same gags. While Fantozzi gradually loses its satirical characteristics to become a more childish and cartoonesque figure, Villaggio's body, on the contrary, becomes visibly older and weaker, physically unable to support the role.Following the transformations of the character and its creator-interpreter, our work intends to propose a journey through the Fantozzi's saga. An audiovisual essay built as a sort of medieval polyptych, in which each chapter can be considered autonomously and, at the same time, as a stage in a wider discourse around one of the most popular figures of postwar Italian cinema

Anomalous vascularization in a Wnt medulloblastoma: A case report

BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children. To date only few cases of medulloblastoma with hemorrhages have been reported in the literature. Although some studies speculate on the pathogenesis of this anomalous increased vascularization in medulloblastoma, the specific mechanism is still far from clearly understood. A correlation between molecular medulloblastoma subgroups and hemorrhagic features has not been reported, although recent preliminary studies described that WNT-subtype tumors display increased vascularization and hemorrhaging. CASE PRESENTATION: Herein, we describe a child with a Wnt-medulloblastoma presenting as cerebellar-vermian hemorrhagic lesion. Brain magnetic resonance imaging (MRI) showed the presence of a midline posterior fossa mass with a cystic hemorrhagic component. The differential diagnosis based on imaging included cavernous hemangioma, arteriovenous malformation and traumatic lesion. At surgery, the tumor appeared richly vascularized as documented by the preoperative angiography. CONCLUSIONS: The case we present showed that Wnt medulloblastoma may be associated with anomalous vascularization. Further studies are needed to elucidate if there is a link between the hypervascularization and the Wnt/β-catenin signaling activation and if this abnormal vasculature might influence drug penetration contributing to good prognosis of this medulloblastoma subgroup

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs

Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers. Among them, stem-like cells (hMB-SLCs) represent a fraction of the tumor cell population with the potential of self-renewal and proliferation and have been associated with tumor poor prognosis. In this context, microRNAs have been described as playing a pivotal role in stem cells differentiation. In our paper, we analyze microRNAs profile and genes expression of hMB-SLCs before and after Retinoic Acid- (RA-) induced differentiation. We aimed to identify pivotal players of specific pathways sustaining stemness and/or tumor development and progression and integrate the results of our recent proteomic study. Our results uncovered 22 differentially expressed microRNAs that were used as input together with deregulated genes and proteins in the Genomatix Pathway System (GePS) analysis revealing 3 subnetworks that could be interestingly involved in the maintenance of hMB-SLCs proliferation. Taken together, our findings highlight microRNAs, genes, and proteins that are significantly modulated in hMB-SLCs with respect to their RA-differentiated counterparts and could open new perspectives for prognostic and therapeutic intervention on MB

Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules

Tubulin-targeting molecules are widely used cancer therapeutic agents. They inhibit microtubule-based structures, including the mitotic spindle, ultimately preventing cell division. The final fates of microtubule-inhibited cells are however often heterogeneous and difficult to predict. While recent work has provided insight into the cell response to inhibitors of microtubule dynamics (taxanes), the cell response to tubulin polymerization inhibitors remains less well characterized. Arylthioindoles (ATIs) are recently developed tubulin inhibitors. We previously identified ATI members that effectively inhibit tubulin polymerization in vitro and cancer cell growth in bulk cell viability assays. Here we characterise in depth the response of cancer cell lines to five selected ATIs. We find that all ATIs arrest mitotic progression, yet subsequently yield distinct cell fate profiles in time-lapse recording assays, indicating that molecules endowed with similar tubulin polymerization inhibitory activity in vitro can in fact display differential efficacy in living cells. Individual ATIs induce cytological phenotypes of increasing severity in terms of damage to the mitotic apparatus. That differentially triggers MCL-1 down-regulation and caspase-3 activation, and underlies the terminal fate of treated cells. Collectively, these results contribute to define the cell response to tubulin inhibitors and pinpoint potentially valuable molecules that can increase the molecular diversity of tubulin-targeting agents

The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia. Relevance to nigral neuronal death and striatal neurochemical changes.

Swiss mice were given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 25 mg/kg/day, for 5 consecutive days and killed at different days after MPTP discontinuance. Decreases in striatal tyrosine hydroxylase activity and levels of dopamine and its metabolites were observed 1 day after MPTP discontinuance. Ascorbic acid and glutamate levels had increased, dehydroascorbic acid and GSH decreased, whereas catabolites of high-energy phosphates (inosine, hypoxanthine, xanthine, and uric acid) were unchanged. In addition, gliosis was observed in both striatum and substantia nigra compacta (SNc). Sections of SNc showed some terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate nick end labeling (TUNEL)-positive cells. Neurochemical parameters of dopaminergic activity showed a trend toward recovery 3 days after MPTP discontinuance. At this time point, TUNEL-positive cells were detected in SNc; some of them showed nuclei with neuronal morphology. A late (days 6-11) increase in striatal dopamine oxidative metabolism, ascorbic acid oxidative status, and catabolites of high-energy phosphates were observed concomitant with nigral neuron and nigrostriatal glial cell apoptotic death, as revealed by TUNEL, acridine orange, and Hoechst staining, and transmission electron microscopy. These data suggest that MPTP-induced activation/apoptotic death of glial cells plays a key role in the sequential linkage of neurochemical and cellular events leading to dopaminergic nigral neuron apoptotic death